Unless the serial LCD is designed to be used that way, there's not really a good way. There are some graphic displays that have a built-in font for use as a 2 x 16 display and you could display bigger characters as graphics, but that's about it.
Here's one graphics display with several different font sizes. The largest displays as 2 x 10.
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Here's one graphics display with several different font sizes. The largest displays as 2 x 10.