Dim cell_value As String Dim ExcelApp As Excel.Application Dim ExcelBook As Excel.Workbook Dim ExcelSheet As Excel.Worksheet ExcelApp = New Excel.Application ExcelBook = ExcelApp.Workbooks.Open("C:\Anybook.xls") 'Add and open the path to workbook 'ExcelApp.Visible = True ExcelSheet = ExcelBook.Worksheets(1) cell_value = ExcelSheet.Cells(1, 1).Value 'Row , Column ExcelSheet = Nothing ExcelBook = Nothing ExcelApp = Nothing